21 August | Thursday, 11:00 CEST
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How do you resolve a tuberculosis outbreak when the strain is nearly clonal and the setting is remote?
In our webinar in August, Dr. Francy Johanna Pérez LLanos will present the genomic investigation of a TB outbreak affecting 74 patients within an indigenous community in the Colombian Amazon. The researchers used both short- and long-read whole genome sequencing (WGS), implementing a customized pipeline based on a local outbreak reference genome and incorporated high-confidence SNPs in repetitive PE/PPE genomic regions. With this approach they were able to improve the phylogenetic resolution and revealed more granular transmission chains and identified mixed infections in nearly 30% of cases.
These findings demonstrate how tailored genomic surveillance strategies can uncover hidden diversity and clarify transmission dynamics in highly clonal Mycobacterium tuberculosis outbreaks.
Come along and learn with us!
