Explain Podcast
The Explain Podcast is for everyone interested in DNA/RNA sequencing or technology.
Two colleagues from the West German Genome Center in Düsseldorf, Bioinformatician Daniel and Scientific Coordinator Iuliia, aim to EXPLAIN key next generation sequencing techniques and how these techniques contribute to our everyday life.
As Iuliia doesn’t have a sequencing background, she learns on the fly and keeps asking “simple” – even silly at times – questions…Daniel gives his best to clarify concepts in simple terms.
The Explain Podcast is recorded at the Multimediazentrum at Heinrich-Heine University of Düsseldorf.
Our podcast is an outreach activity within the national genomics facility ”West German Genome Center” funded by DFG No. 407493903 and MKW NRW.
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Enjoy and let us know what you think about our podcast!
we’re happy to receive your feedback – write us podcast|dot|explain|at|gmail.com
YOU can contribute to making our Explain Podcast better – don’t miss a chance!
The Podcast Explain is for everyone interested in DNA/RNA sequencing or technology in general. As Iuliia doesn’t have a solid background in sequencing, she keeps asking “simple” – even silly at times – questions and Daniel gives his best to make us understand.
Because sometimes a jellyfish prevents quenching
Chapters:
01:00 – XLeap update from Illumina
08:00 – Avidites start, splitting the problems
13:20 – In-depth comparison to Illumina
22:00 – Element summary
23:30 – Bioinformatics tools: Jellyfish, KAT
25:00 – QuickGen: GWAS
Illumina about their XLeap: https://www.illumina.com/science/genomics-research/articles/data-quality-q-scores.html
Sandiegomics about element: https://sandiegomics.com/element-beats-illumina-to-the-200-genome/
Nature paper about the chemistry: https://www.nature.com/articles/s41587-023-01750-7
Jellyfish for k-mer counting: https://github.com/gmarcais/Jellyfish
GWAS Catalog: very nice data collection: https://www.ebi.ac.uk/gwas/diagram
Correcting population-based GWAS bias: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011242
Since 2018, West German Genome Center (https://wggc.de/) operates as the next generation sequencing facility and supports research in genomics & transcriptomics by providing expertise and sequencing services. WGGC is a part of the Next Generation Sequencing Competence Network (NGS-CN: https://ngs-kn.de/) – network of NGS core facilities in Germany. Listen to our podcast and we're happy to receive your feedback&questions via Email (podcast[dot]explain[at]gmail[dot]com ).
